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HPV-negative HPV Primary Screening Clinical Pathway Age cohort 50 to 69 years (provider-collected) Provider-collected HPV test HPV-positive High-risk other strain (immunocompetent) HPV-positive High-risk other strain (immunocompromised) Reflex LBC* LBC automatically done by lab Normal/ASCUS/LSIL ASC-H/HSIL/AGC/AIS HPV-positive 16/18 Invalid Reflex LBC LBC automatically done by lab Repeat HPV test in 1…

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Primary care provider results follow-up Result group Normal Abnormal HPV primary result (High-risk HPV NAT) Not detected (aged 50 to 64) Not detected (aged 65 to 69) Detected HPV 16 and/or 18 + Unsatisfactory, NIL, ASCUS, LSIL, ASCH, HSIL, AGC, AIS Detected other HR HPV (Immunocompromised) + Unsatisfactory, NIL, ASCUS,…